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The medical use of cannabis was advocated in the United States in the 1970s and 1980s when clinical trials of oral synthetic tetrahydrocannabinol (THC) and other oral synthetic cannabinoids reported efficacy in controlling nausea in patients with cancer who were undergoing chemotherapy.1 Dronabinol (an oral synthetic THC) was approved by the Food and Drug Administration in 1985 for this indication,1 but it was not widely used because patients were unable to titrate doses or disliked its psychoactive effects.1 It is still available in the US, United Kingdom, and the rest of Europe. Box 1 outlines the different formulations of cannabinoids, the term we use for the sake of clarity and convenience to refer to synthetic cannabinoids and drugs derived from the cannabis plant, such as nabiximols. Box 2 lists indications for which cannabinoids have been approved for medical use. #### Box 1: Forms of cannabis and cannabinoids #### Box 2: Approved medical uses for tetrahydrocannabinol and nabiximols In the …
Farrell et al. (Wed,) studied this question.