Divergolides A–D from a Mangrove Endophyte Reveal an Unparalleled Plasticity in ansa‐Macrolide Biosynthesis

In-built diversification: Four ansa macrolides, divergolides A–D (1–4), with intriguing structures were isolated from a bacterial endophyte of the mangrove tree Bruguiera gymnorrhiza. These compounds are generated by a common biogenesis from a linear precursor that undergoes various reactions to give the multicyclic structures. This remarkable plasticity results in metabolites with different antibacterial and cytotoxic properties. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.