Higher post-ablation hs-CRP levels were found in patients with atrial fibrillation recurrence compared to non-recurrent patients (WMD 0.09; 95% CI 0.03-0.15; p<0.001).
Meta-Analysis (n=789)
Are high sensitivity C reactive protein (hs-CRP) levels associated with atrial fibrillation recurrence after catheter ablation?
Post-ablation, but not baseline, hs-CRP levels are significantly higher in patients who experience AF recurrence after catheter ablation, suggesting a potential role as a predictive biomarker.
Effect estimate: WMD 0.09 (95% CI 0.03-0.15)
p-value: p=<0.001
Abstract Background Atrial fibrillation (AF) recurrence after AF ablation is not uncommon. High sensitivity C reactive protein (hs‐CRP) is a widely used inflammatory marker with a potential property to predict AF recurrence. We conducted a systematic review and a meta‐analysis to find an association between hs‐CRP levels and AF recurrence after ablation. Methods We searched PubMed, Embase, and Wiley‐Cochrane Library from inception to January 2022 for studies that reported hs‐CRP levels in patients who underwent AF ablation. Weighted mean difference (WMD) was used to evaluate the difference between hs‐CRP levels in post‐ablation AF recurrent and non‐recurrent group. Also, the difference between hs‐CRP levels in pre‐ and post‐ablation was determined. Results We identified 10 studies, and a total of 789 patients were included (299 recurrent vs. 490 non‐recurrent patients). The mean age was 57.7 years (76.4% male). There was no difference in baseline hs‐CRP levels between AF recurrent and non‐recurrent group (WMD = 0.05, 95% CI = −0.04 to 0.15, p = 0.045). However, higher hs‐CRP levels post‐ablation were found in AF recurrent group (WMD = 0.09, 95% CI = 0.03–0.15, p < 0.001). Conclusion There is no significant difference in baseline hs‐CRP levels between AF recurrent and non‐recurrent patients after AF ablation. However, higher post‐ablation hs‐CRP level was found in AF recurrent group. High Sensitivity C reactive protein may play a role as a predictor of AF recurrence.
Jaroonpipatkul et al. (Tue,) conducted a meta-analysis in Atrial fibrillation (n=789). hs-CRP levels vs. AF non-recurrent group was evaluated on Difference in post-ablation hs-CRP levels between AF recurrent and non-recurrent groups (WMD 0.09, 95% CI 0.03-0.15, p=<0.001). Higher post-ablation hs-CRP levels were found in patients with atrial fibrillation recurrence compared to non-recurrent patients (WMD 0.09; 95% CI 0.03-0.15; p<0.001).