Carotid plaque assessment reclassified significantly more inflammatory bowel disease patients into the very high-cardiovascular-risk category compared to controls (35% vs 24%, p=0.030).
Cross-Sectional (n=361)
Does carotid plaque assessment by ultrasound facilitate the reclassification of patients with inflammatory bowel disease into the very high-CV-risk category compared to controls?
Carotid ultrasound plaque assessment effectively reclassifies a significant proportion of IBD patients, even those initially deemed low-risk, into the very high cardiovascular risk category.
Absolute Event Rate: 35% vs 24%
p-value: p=0.030
The addition of carotid ultrasound into cardiovascular (CV) risk scores has been found to be effective in identifying patients with chronic inflammatory diseases at high-CV risk. We aimed to determine if its use would facilitate the reclassification of patients with inflammatory bowel disease (IBD) into the very high-CV-risk category and whether this may be related to disease features. In this cross-sectional study encompassing 186 IBD patients and 175 controls, Systematic Coronary Risk Evaluation (SCORE), disease activity measurements, and the presence of carotid plaques by ultrasonography were assessed. Reclassification was compared between patients and controls. A multivariable regression analysis was performed to evaluate if the risk of reclassification could be explained by disease-related features and to assess the influence of traditional CV risk factors on this reclassification. After evaluation of carotid ultrasound, a significantly higher frequency of reclassification was found in patients with IBD compared to controls (35% vs. 24%, p = 0.030). When this analysis was performed only on subjects included in the SCORE low-CV-risk category, 21% IBD patients compared to 11% controls (p = 0.034) were reclassified into the very high-CV-risk category. Disease-related data, including disease activity, were not associated with reclassification after fully multivariable regression analysis. Traditional CV risk factors showed a similar influence over reclassification in patients and controls. However, LDL-cholesterol disclosed a higher effect in controls compared to patients (beta coef. 1.03 (95%CI 1.02–1.04) vs. 1.01 (95%CI 1.00–1.02), interaction p = 0.035) after adjustment for confounders. In conclusion, carotid plaque assessment is useful to identify high-CV risk IBD patients.
Hernández-Camba et al. (Tue,) conducted a cross-sectional in Inflammatory bowel disease (n=361). Carotid plaque assessment by ultrasonography vs. Controls was evaluated on Reclassification into the very high-cardiovascular-risk category (p=0.030). Carotid plaque assessment reclassified significantly more inflammatory bowel disease patients into the very high-cardiovascular-risk category compared to controls (35% vs 24%, p=0.030).
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