The voltage-gated KCNQ1 potassium channel plays a crucial role in shaping the cardiac action potential and controlling water and salt homeostasis, tightly regulated by auxiliary proteins.
The voltage-gated KCNQ1 (KvLQT1, Kv7.1) potassium channel plays a crucial role in shaping the cardiac action potential as well as in controlling the water and salt homeostasis in several epithelial tissues. KCNQ1 channels in these tissues are tightly regulated by auxiliary proteins and accessory factors, capable of modulating the properties of the channel complexes. This paper reviews the current knowledge about the KCNQ1 channel with a major focus on interacting proteins and physiological functions.
Jespersen et al. (Tue,) conducted a review in KCNQ1 channel function. The voltage-gated KCNQ1 potassium channel plays a crucial role in shaping the cardiac action potential and controlling water and salt homeostasis, tightly regulated by auxiliary proteins.