December 1, 2017Open Access

CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

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Abstract

DCs, and M2 macrophages decreased, suggesting that "iIL18 TRUCKs" can be used to sensitize large solid tumor lesions for successful immune destruction.

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Chmielewski et al. (Fri,) studied this question.

synapsesocial.com/papers/6a128683a4bed3c7b1674250 https://doi.org/https://doi.org/10.1016/j.celrep.2017.11.063

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