General anesthesia was associated with a similar incidence of intraoperative awareness compared to other anesthetic modalities (0.023% vs 0.03%; RR 0.74; 95% CI 0.28-2.0; P=0.54).
Observational (n=116,478)
No
Does general anesthesia increase the incidence of intraoperative awareness compared to other types of anesthesia in adult surgical patients?
Retrospective database analyses may lack the resolution to accurately study rare events like intraoperative awareness, as no difference was found between general and non-general anesthesia.
Effect estimate: RR 0.74 (95% CI 0.28-2.0)
Absolute Event Rate: 0.023% vs 0.03%
p-value: p=0.54
BACKGROUND: Awareness during general anesthesia is a problem receiving increased attention from physicians and patients. Large multicentered studies have established an accepted incidence of awareness during general anesthesia as approximately 1-2 per 1000 cases or 0.15%. More recent retrospective data, however, suggest that the actual incidence may be as low as 0.0068%. METHODS: To assess the incidence of awareness at our institution, we conducted a review of adult patients undergoing surgical procedures over a 3-year period. Information on awareness came from entries of "Intraoperative Awareness" captured during our standard evaluations on postoperative day one in our perioperative information system. Patients were not questioned specifically about awareness. RESULTS: We reviewed 116,478 charts; 65,061 patients received general anesthesia and 51,417 received other types of anesthesia. Of the patients receiving general anesthesia, 44,006 had complete postoperative documentation. The reported incidence of undesired intraoperative awareness in this population was 10/44,006 (1/4401 or 0.023%). Of the patients who received other anesthetic modalities, 22,885 had complete postoperative documentation. Undesired intraoperative awareness was reported in 7/22,885 patients who did not receive general anesthesia (1/3269 or 0.03%). The reported incidence of intraoperative awareness was not statistically different between the two groups (P = 0.54). Relative risk of intraoperative awareness during a general anesthetic compared with a nongeneral anesthetic was 0.74, with 95% confidence interval 0.28, 2.0. CONCLUSION: Using a retrospective methodology, reports of intraoperative awareness are not statistically different in patients who received general anesthesia compared with those who did not. These results suggest that, despite success with other rare perioperative events, the resolution of retrospective database analyses may be too low to study intraoperative awareness.
Mashour et al. (Wed,) conducted a observational in Surgical procedures (n=116,478). General anesthesia vs. Other types of anesthesia was evaluated on Undesired intraoperative awareness (RR 0.74, 95% CI 0.28-2.0, p=0.54). General anesthesia was associated with a similar incidence of intraoperative awareness compared to other anesthetic modalities (0.023% vs 0.03%; RR 0.74; 95% CI 0.28-2.0; P=0.54).