Proinflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6, play an important role in the pathogenesis of chronic heart failure by influencing cardiac contractility and remodeling.
Activation of the cytokine system in chronic heart failure is a marker of disease progression and highlights the pathophysiological role of inflammation in cardiac remodeling.
Accumulating evidence indicates that cytokines play an important role in the pathogenesis of chronic heart failure. The review considers the participation of proinflammatory cytokines (factors-necroses-tumors-α, interleukin 1β and interleukin 6) in the pathophysiological processes of congestive heart failure, as well as the influence of proinflammatory cytokines on cardiac contractility, hypertrophy and remodeling of the left ventricle of the heart, apoptotic, and fibrotic processes.
Осипова et al. (Sun,) conducted a review in Chronic heart failure. Proinflammatory cytokines, including TNF-alpha, IL-1beta, and IL-6, play an important role in the pathogenesis of chronic heart failure by influencing cardiac contractility and remodeling.
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