This review outlines pathophysiological mechanisms, diagnostic tools including MRI and biopsy, and novel targeted therapies to improve outcomes in pediatric acute myocarditis.
This review provides an update on the pathophysiology, diagnostic tools, and therapeutic strategies for acute myocarditis in children to improve short- and long-term outcomes.
Acute viral myocarditis may impair prognosis in children of all ages. Its true incidence is underestimated because of heterogeneity of presentation and outcome. Patients may either recover or progress to chronic cardiomyopathy or death. Improving short-term and long-term prognosis is challenging but can probably be achieved by new diagnostic techniques and novel targeted therapies. The objectives of this review are: (1) to detail the current state of knowledge of the pathophysiological mechanisms of acute myocarditis; (2) to provide an update on diagnostic tools such as magnetic resonance imaging and endomyocardial biopsy; and (3) to present new insights in therapeutic strategies, targeted therapies and management of fulminant cases. Options for improving outcomes in acute myocarditis in the pediatric population are discussed.
Sylvie Di Filippo (Fri,) conducted a review in Acute viral myocarditis. Diagnostic tools and targeted therapies was evaluated. This review outlines pathophysiological mechanisms, diagnostic tools including MRI and biopsy, and novel targeted therapies to improve outcomes in pediatric acute myocarditis.
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