Rodent animal models play an essential role in investigating the mechanisms underlying the protection premenopausal females have against cardiovascular disease, specifically hypertension and atherosclerosis.
This review highlights the utility of rodent models in understanding sex differences in cardiovascular disease, specifically hypertension and atherosclerosis.
Approximately one third of all deaths are attributed to cardiovascular disease (CVD), making it the biggest killer worldwide. Despite a number of therapeutic options available, the burden of CVD morbidity continues to grow indicating the need for continued research to address this unmet need. In this respect, investigation of the mechanisms underlying the protection that premenopausal females enjoy from cardiovascular-related disease and mortality is of interest. In this review, we discuss the essential role that rodent animal models play in enabling this field of research. In particular, we focus our discussion on models of hypertension and atherosclerosis.
Bubb et al. (Tue,) conducted a review in Hypertension and atherosclerosis. Rodent animal models play an essential role in investigating the mechanisms underlying the protection premenopausal females have against cardiovascular disease, specifically hypertension and atherosclerosis.
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