Elevated HbA1c (≥6.5%) combined with high CRP (>10 mg/L) was significantly associated with severe double and triple vessel coronary artery disease in patients with ischemic heart disease.
Cross-Sectional (n=668)
No
Are elevated CRP and HbA1c levels associated with increased severity of coronary artery disease in patients with ischemic heart disease?
Elevated CRP and HbA1c jointly correlate with more severe angiographic coronary artery disease in patients presenting with ischemic heart disease.
p-value: p=0.001
Background: C-reactive protein (CRP) and glycohemoglobin (HbA1c) are established risk factors for the development of cardiovascular disease. We investigated the joint effects of these parameters on the severity of coronary artery disease (CAD) in patients with ischemic heart disease.Methods: This cross sectional study was performed on 668 patients of ischemic heart disease. CRP value were divided into normal (10 mg/L) and HbA1c was divided 50% stenosis and single vessel, double vessel, triple vessel CAD and normal coronaries.Results: Most (65.0%) of the patients belonged to age 41-60 years. The mean age was found 51.4±10.7 years. Majority (82.3%) of patients were male. Among risk factors, highest (40.0%) patients had hypertension followed by 209 (31.3%) diabetes mellitus and 204 (30.5%) smoker. The relationship of CRP with the whole spectrum of ischemic heart disease was found statistically significant (p<0.05). The relationship of HbA1c and CRP were significantly associated with the severity of coronary artery disease. At HbA1c e”6.5 percent, severe CAD (double vessel and triple vessel) were found higher in high CRP than normal and borderline CRP group.Conclusion: Inflammation, presented by CRP, and hyperglycemia, presented by HbA1c, jointly contributes to the cardiovascular risk of patients. Patients with high CRP and elevated HbA1c are associated with severe coronary artery diseases.Cardiovasc. j. 2018; 11(1): 53-58
Ahmed et al. (Fri,) conducted a cross-sectional in Ischemic heart disease (n=668). High CRP (>10 mg/L) and elevated HbA1c (≥6.5%) vs. Normal/borderline CRP and HbA1c <6.5% was evaluated on Severity of coronary artery disease (extent of stenosis) (p=0.001). Elevated HbA1c (≥6.5%) combined with high CRP (>10 mg/L) was significantly associated with severe double and triple vessel coronary artery disease in patients with ischemic heart disease.
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