Haematopoietic stem cell transplantation in children was associated with significantly elevated ET-1 and NT-proBNP plasma levels and lower E/A ratios compared to healthy controls.
Observational (n=44)
No
Do biochemical markers and echocardiographic parameters indicate early cardiotoxicity in children treated with haematopoietic stem cell transplantation?
Elevated ET-1 and NT-proBNP levels, along with reduced E/A ratio, suggest subclinical early cardiotoxicity in children undergoing HSCT, highlighting the need for careful cardiac follow-up.
Absolute Event Rate: 0.52% vs 0.22%
p-value: p=<0.001
Cardiotoxicity is one of the complications following haematopoietic stem cell transplantation (HSCT), but its diagnosis may be hampered due to the presence of different post-transplant comorbidities. The aim of the study was to assess the incidence of cardiac complications and the significance of biochemical markers (NT-proBNP, ANP, ET-1, and TnI) and ECHO systolic and diastolic parameters analysis in children treated with HSCT. Thirty consecutive children (median age 9.6 years) were included in the study. The control group consisted of 14 healthy children (median age of 10.9 years). None of the transplanted children developed clinical cardiotoxicity. Median ET-1 and NT-proBNP plasma levels were elevated when compared to controls in at least 3 out of 4 analysed time points, median ANP levels differed only in one time point, and no difference was found between median TnI values in all analysed time points. Echocardiographic systolic parameters were within the normal range, while median E/A ratio assessed before HSCT, on day +30, and +100 post-transplant was statistically lower in HSCT patients (respectively, 1.34, 1.37, and 1.42 vs. 1.73). It confirms the need for careful follow up in patients who have received chemotherapy and have been treated with HSCT.
Zaucha‐Prażmo et al. (Fri,) conducted a observational in Children undergoing haematopoietic stem cell transplantation (n=44). Haematopoietic stem cell transplantation (HSCT) vs. Healthy controls was evaluated on Median ET-1 plasma level on day +7 post-transplant (fmol/ml) (p=<0.001). Haematopoietic stem cell transplantation in children was associated with significantly elevated ET-1 and NT-proBNP plasma levels and lower E/A ratios compared to healthy controls.