A holistic, adiposity-related disease framework enhances the diagnosis and management of obesity by addressing adipose tissue dysfunction and its diverse systemic complications.
This review advocates for a holistic, adiposity-based chronic disease framework to improve the diagnosis and management of obesity beyond simple BMI metrics.
Obesity is a complex disease that relapses frequently and associates with multiple complications that comprise a worldwide health priority because of its rising prevalence and association with numerous complications, including metabolic disorders, mechanic pathologies, and cancer, among others. Noteworthy, excess adiposity is accompanied by chronic inflammation, oxidative stress, insulin resistance, and subsequent organ dysfunction. This dysfunctional adipose tissue is initially stored in the visceral depot, overflowing subsequently to produce lipotoxicity in ectopic depots like liver, heart, muscle, and pancreas, among others. People living with obesity need a diagnostic approach that considers an exhaustive pathophysiology and complications assessment. Thus, it is essential to warrant a holistic diagnosis and management that guarantees an adequate health status, and quality of life. The present review summarizes the different complications associated with obesity, at the same time, we aim to fostering a novel framework that enhances a patient-centered approach to obesity management in the precision medicine era.
Perdomo et al. (Wed,) conducted a review in Obesity. A holistic, adiposity-related disease framework enhances the diagnosis and management of obesity by addressing adipose tissue dysfunction and its diverse systemic complications.