A single cardiac troponin T measurement 96 hours after LAD ligation in dogs was highly predictive of relative infarct size (r=0.74, p=0.0010), comparable to peak or cumulative levels.
Does a single measurement of cTnT at 96 hours accurately estimate myocardial infarct size compared to serial sampling in a canine model of LAD ligation?
A single measurement of cardiac troponin T at 96 hours provides a practical and cost-effective estimation of myocardial infarct size in a canine model.
Effect estimate: r = 0.74
p-value: p=0.0010
We determined the utility of single-point measurements of circulating cardiac troponin T (cTnT) for the noninvasive estimation of infarct size in 16 beagle dogs after left anterior descending artery (LAD) ligation. Pathoanatomical infarct sizes were determined by the triphenyltetrazolium chloride method and correlated with serum concentration changes of cTnT. Peak cTnT levels (14.10 +/- 4.71 microg/l) were reached after 110 +/- 21 h. A significant correlation was found between peak cTnT levels (p = 0.0001, r = 0. 83) or cumulative cTnT levels and relative infarct size (p = 0.0010, r = 0.72). A single cTnT measurement 96 h after LAD ligation was equally predictive of infarct size (p = 0.0010, r = 0.74) as peak or cumulative cTnT levels derived from serial sampling. cTnT levels at 96 h may thus be useful for practical and cost-effective estimation of infarct size.
Remppis et al. (Sat,) conducted a other in Myocardial Infarction (n=16). Single cTnT measurement at 96 hours vs. Peak or cumulative cTnT levels from serial sampling was evaluated on Correlation with relative infarct size (r = 0.74, p=0.0010). A single cardiac troponin T measurement 96 hours after LAD ligation in dogs was highly predictive of relative infarct size (r=0.74, p=0.0010), comparable to peak or cumulative levels.
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