June 13, 2018Open Access

Population Pharmacokinetics and Cerebrospinal Fluid Penetration of Fluconazole in Adults with Cryptococcal Meningitis

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Abstract

The meta-analysis suggested modest improvements in both CSF sterility and mortality outcomes with escalating dosage. This study provides the pharmacodynamic rationale for the long-recognized fact that fluconazole monotherapy is an inadequate induction regimen for CM.

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Stott et al. (Wed,) studied this question.

synapsesocial.com/papers/6a17a1158008e5848e6edf18 https://doi.org/https://doi.org/10.1128/aac.00885-18

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1Microevolution of Serial Clinical Isolates ofCryptococcus neoformansvar.grubiiandC. gattii2017 · 86 citations
2Treatment of cryptococcal meningitis in mice with fluconazole1986 · 61 citations
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4P450 inhibitors of use in medical treatment: Focus on mechanisms of action1995 · 150 citations
5Discovery of Fluconazole, a Novel Antifungal Agent1990 · 134 citations

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