Do three new long-acting converting-enzyme inhibitors reduce blood pressure response to angiotensin I and plasma converting-enzyme activity in men?
Two new long-acting angiotensin converting-enzyme inhibitors demonstrated marked and prolonged inhibition of plasma converting-enzyme activity and blood pressure response to angiotensin I up to 24 hours post-dose.
Three new angiotensin converting-enzyme inhibitors were given orally to 20 men in single doses ranging from 1.25 to 40 mg. Two of them induced comparable marked inhibition of both the blood pressure response to exogenous angiotensin I and plasma converting-enzyme activity. Onset of action was relatively slow, but 21 to 24 hr after drug plasma converting-enzyme activity was still clearly reduced. The third was less active. There was a close correlation between blood pressure response on administration of angiotensin I and plasma converting-enzyme activity. There were no adverse effects. These new drugs are interesting because of their long duration of action. The measurement of plasma converting-enzyme activity seems useful for monitoring efficacy of converting-enzyme blockade and compliance to therapy.
Biollaz et al. (Fri,) studied this question.