What question did this study set out to answer?

The aim is to develop a transition metal-free method for synthesizing benzimidazopurines and benzimidazoquinazolines via C-N bond formation.

May 28, 2026Chemical Communications0 citations

K₂S₂O₈-enabled one-pot deaminative C-N bond formation for the synthesis of fused benzimidazopurines and benzimidazoquinazolines

SMSamir Kumar MondalIndian Institute of Technology Bhubaneswar MRManthri Atchuta RaoIndian Institute of Technology Bhubaneswar SSSakshi SinghUniversity of Notre Dame

Key Points

The aim is to develop a transition metal-free method for synthesizing benzimidazopurines and benzimidazoquinazolines via C-N bond formation.
Utilized K₂S₂O₈ as an oxidizing agent for intramolecular C-N bond formation.
Employed a one-pot reaction strategy for efficiency.
Focused on the synthesis of benzimidazole derivatives without transition metals.
Successfully synthesized various fused benzimidazopurines and benzimidazoquinazolines.
The method showcased high selectivity and yield for desired products.

Abstract

We report an unusual, transition metal-free oxidative cyclization strategy for the synthesis of benzoimidazopurine and benzoimidazoquinazoline derivatives via K₂S₂O₈-enabled intramolecular C-N bond formation. The reaction proceeds through an oxidative deamination...

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