Update in Hematology

Updates from the Annual Session15 January 2002Update in HematologyJoseph P. Catlett, MD and Barbara M. Alving, MDJoseph P. Catlett, MDFrom Washington Hospital Center, Washington, D.C.; and National Institutes of Health, Bethesda, Maryland.Search for more papers by this author and Barbara M. Alving, MDFrom Washington Hospital Center, Washington, D.C.; and National Institutes of Health, Bethesda, Maryland.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-136-2-200201150-00011 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail In the past several years, there has been a veritable explosion of new and impressive treatments that not only will alter the management of leukemia and lymphoma but are expected to have far-reaching effects in general internal medicine. Target-specific drugs, including monoclonal antibodies and selective enzyme inhibitors—along with so-called designer drugs—have ushered in a new era in medicine. Examples in this Update are rituximab, a monoclonal antibody effective in non-Hodgkin lymphoma and the oral antileukemia drug STI-571. We also discuss advances in the following areas of hematology: self-management of oral anticoagulant therapy, understanding risks for venous thromboembolism in women during ...References1. McLaughlin P, Grillo-López AJ, Link BK, Levy R, Czuczman MS, Williams ME, et al . Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol. 1998;16:2825-33. PMID: 9704735 CrossrefMedlineGoogle Scholar2. Atkinson K, Horowitz MM, Gale RP, Lee MB, Rimm AA, Bortin MM. Consensus among bone marrow transplanters for diagnosis, grading and treatment of chronic graft-versus-host disease. Committee of the International Bone Marrow Transplant Registry. Bone Marrow Transplant. 1989;4:247-54. PMID: 2659110 MedlineGoogle Scholar3. Stasi R, Pagano A, Stipa E, Amadori S. Rituximab chimeric anti-CD20 monoclonal antibody treatment for adults with chronic idiopathic thrombocytopenic purpura. Blood. 2001;98:952-7. PMID: 11493438 CrossrefMedlineGoogle Scholar4. Hylek EM, Chang YC, Skates SJ, Hughes RA, Singer DE. Prospective study of the outcomes of ambulatory patients with excessive warfarin anticoagulation. Arch Intern Med. 2000;160:1612-7. PMID: 10847254 CrossrefMedlineGoogle Scholar5. Ginsberg JS, Greer I, Hirsh J. Use of antithrombotic agents during pregnancy. Chest. 2001;119:122S-131S. PMID: 11157646 CrossrefMedlineGoogle Scholar6. Charache S, Terrin ML, Moore RD, Dover GJ, Barton FB, Eckert SV, et al . Effect of hydroxyurea on the frequency of painful crises in sickle cell anemia. Investigators of the Multicenter Study of Hydroxyurea in Sickle Cell Anemia. N Engl J Med. 1995;332:1317-22. PMID: 7715639 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: From Washington Hospital Center, Washington, D.C.; and National Institutes of Health, Bethesda, Maryland.Corresponding Author: Joseph P. Catlett, MD, Hematology/Oncology Section, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010-2975.Current Author Addresses: Dr. Catlett: Hematology/Oncology Section, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010-2975.Dr. Alving: National Heart, Lung, and Blood Institute, National Institutes of Health, Building 31, Room 5A 47, 10 Center Drive, Bethesda, MD 20892-2490. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited by2006 Update of Recommendations for the Use of White Blood Cell Growth Factors: An Evidence-Based Clinical Practice GuidelineThe use of recombinant factor VIIa in the treatment of bleeding disorders 15 January 2002Volume 136, Issue 2Page: 136-143KeywordsCellsChronic myelocytic leukemiaInternational normalized ratioLymphomaPlateletsPregnancyPulmonary embolismThoraxVenous thromboembolismVitamin K ePublished: 15 January 2002 Issue Published: 15 January 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...