Magnetic resonance tissue phase mapping demonstrated that increased age reduces diastolic long-axis velocities (P<0.003), and women have reduced systolic twist compared to men (P=0.009).
Observational (n=58)
Does age and gender influence regional myocardial motion assessed by magnetic resonance tissue phase mapping in healthy volunteers?
Age and gender significantly influence regional myocardial motion, establishing the necessity for age- and gender-matched reference values when using magnetic resonance tissue phase mapping.
BACKGROUND: An exact understanding of normal age- and gender-matched regional myocardial performance is an essential prerequisite for the diagnosis of heart disease. Magnetic resonance phase-contrast imaging (tissue phase mapping) enabling the analysis of segmental, 3-directional myocardial velocities with high temporal resolution (13. 8 ms) was used to assess left ventricular motion. METHODS AND RESULTS: Radial, long-axis, and rotational myocardial velocities were acquired in 58 healthy volunteers (3 age groups, 29 women) in left ventricular basal, midventricular, and apical short-axis locations. For increased age, reduced (P<0. 003) and prolonged long-axis and radial velocities (P<0. 05) during diastole and reduced long-axis velocities (P<0. 001) and apical rotation (P<0. 005) during systole were found for both genders. Women demonstrated a reduced systolic twist (P=0. 009), apical rotation (P=0. 01), and systolic radial velocities (P<0. 02) compared with men. Segmental analysis of long-axis motion with aging revealed differences in regional reduction of systolic (lateral 52% versus 30%) and diastolic (lateral 57% versus 41%) velocities in women compared with men. In basal segments, young women demonstrated higher long-axis velocities (+11% during diastole) than men, whereas this difference was reversed in older subjects (same segments, -20%). In addition, increased age resulted in a prolonged time to peak diastolic apical rotation (P<0. 04) in women compared with men. CONCLUSIONS: Age and gender strongly influence regional myocardial motion. Tissue phase mapping provides a comprehensive quantitative analysis of all myocardial velocities with high temporal and spatial resolution. The knowledge of the detected age- and gender-related differences in myocardial motion is fundamental for further investigations of cardiac disease. Clinical Trial Registration- http: //www. zks. uni-freiburg. de/uklreg/php/suchergebnisₐll. php. Identifier: UKF001739.
Föll et al. (Wed,) conducted a observational in Healthy volunteers (n=58). Magnetic resonance phase-contrast imaging (tissue phase mapping) vs. Age and gender groups was evaluated on Radial, long-axis, and rotational myocardial velocities. Magnetic resonance tissue phase mapping demonstrated that increased age reduces diastolic long-axis velocities (P<0.003), and women have reduced systolic twist compared to men (P=0.009).