Kangfuxin solution perianal warm moist compress combined with music therapy for anal fullness after endoscopic treatment of internal hemorrhoids

Background Anal fullness commonly occurs following endoscopic treatment of internal hemorrhoids, yet targeted nursing interventions remain limited. This study evaluated the individual and combined effects of Kangfuxin solution ( Periplaneta americana extract) perianal warm moist compress and music therapy on this symptom. Methods In this prospective 2 × 2 factorial-design study, 120 patients with Grade II/III internal hemorrhoids undergoing endoscopic treatment were randomized ( n = 30 per group): Kangfuxin compress plus music therapy (A), Kangfuxin compress alone (B), music therapy alone (C), and routine care (D). Interventions were administered twice daily for 5 days. Outcomes included anal fullness (Visual Analogue Scale VAS), symptom duration, quality of life (WHOQOL-BREF), and therapeutic efficacy. Factorial main effects and interaction were assessed using two-way ANOVA. Results Group A showed significantly lower VAS scores at all postoperative time points (all p 0.05), reaching 0.82 ± 0.53 by day 7 versus 2.53 ± 0.88 in Group D. Generalized estimating equations confirmed a significant time-by-intervention interaction ( p 0.001). Two-way factorial ANOVA revealed significant main effects for both the Kangfuxin solution factor ( F = 42.15, p 0.001) and the music therapy factor ( F = 15.83, p 0.001), with a non-significant interaction ( F = 0.42, p = 0.518), indicating additive rather than synergistic effects. Symptom duration was shortest in Group A (3.85 ± 1.12 days) versus Groups B (4.76 ± 1.25), C (5.92 ± 1.38), and D (7.21 ± 1.56; all p 0.05). Group A achieved the highest WHOQOL-BREF scores and total effective rate (96.67% vs. 70.00%). Intervention method was the strongest predictor of quality of life ( β = 0.682, p 0.001). Adverse events were limited to mild skin reactions (2.5%). Conclusion Kangfuxin solution perianal warm moist compress combined with music therapy effectively alleviates anal fullness, shortens symptom duration, and improves quality of life after endoscopic hemorrhoid treatment. The two interventions exert additive benefits, and their combination outperforms either modality alone. This safe multimodal intervention warrants integration into postoperative nursing protocols.