In Vitro Effects of C-Reactive Protein on Phagocytosis

Hokama, Y. (University of California, Los Angeles), Monroe K. Coleman, and Richard F. Riley. In vitro effects of C-reactive protein on phagocytosis. J. Bacteriol. 83:1017-1024. 1962. Carbonyl iron spherules, Diplococcus pneumoniae types IIs and XXVIIs, and Serratia marcescens were phagocytosed more rapidly and in greater numbers by leukocytes of normal human blood after incubation with C-reactive protein. With the exception of carbonyl iron spherules, addition of C-reactive protein to whole blood containing substrate had little effect on the extent of phagocytosis. Normal and acute-phase seromucoid Escherichia coli lipopolysaccharide and crude endogenous pyrogen were without a stimulating effect under the same conditions in the homologous systems employed.