Aortic valve replacement for degenerative aortic stenosis significantly reduced left ventricular mass index from 156 g/m2 preoperatively to 140 g/m2 postoperatively.
Cohort (n=358)
No
Does aortic valve replacement decrease left ventricular mass and improve left ventricular function in patients with degenerative aortic stenosis?
Aortic valve replacement for degenerative aortic stenosis leads to significant and sustained reduction in left ventricular mass and improvement in left ventricular function.
Absolute Event Rate: 140% vs 156%
p-value: p=<0.001
BACKGROUND: Left ventricular (LV) hypertrophy caused by aortic valve stenosis (AS) leads to cardiovascular morbidity and mortality. We sought to determine whether aortic valve replacement (AVR) decreases LV mass and improves LV function. MATERIALS AND METHODS: Retrospective review for 358 consecutive patients, who underwent aortic valve replacement for degenerative AS between January 1995 and December 2008, was performed. There were 230 men and 128 women, and their age at operation was 63.2±10 years (30~85 years). RESULTS: There was no in-hospital mortality, and mean follow-up duration after discharge was 48.9 months (2~167 months). Immediate postoperative echocardiography revealed that LV mass index and mean gradient across the aortic valve decreased significantly (p7) (p=0.045) were risk factors for late death. CONCLUSION: After AVR for degenerative AS, reduction of left ventricular mass and improvement of left ventricular function continue late after operation.
Shin et al. (Wed,) conducted a cohort in Degenerative aortic stenosis (n=358). Aortic valve replacement vs. Preoperative baseline was evaluated on Left ventricular mass index (g/m2) (p=<0.001). Aortic valve replacement for degenerative aortic stenosis significantly reduced left ventricular mass index from 156 g/m2 preoperatively to 140 g/m2 postoperatively.