MRI Demonstrates Dorsal Column Involvement of the Spinal Cord in Sjogren's syndrome-associated Neuropathy

Sjogren's syndrome (SS) is occasionally associated with chronic sensory ataxic and autonomic neuropathy, 1-4 the major pathology of which is dorsal root ganglionitis with T-cell invasion, 1 and possibly sympathetic and ciliary ganglionitis 5. There is loss of the large dorsal root ganglion neurons and secondary loss of the axons in the central rami of the sensory neurons 1,4,5. In this study, we investigated the MRI findings of dorsal column involvement in the spinal cords of three patients with SS-associated chronic sensory ataxic neuropathy. Case reports. A 56-year-old woman (patient 1) initially developed numbness and dysesthesia in the fingers and face when she was 47 years old, which over several years gradually spread to involve the hands and legs. She subsequently showed an unsteady gait. Xerostomia and xerophthalmia were apparent. Bilateral Adie's pupils were present. There was loss of vibratory and joint position sense in the four extremities. Sensation of light touch and pain was impaired in the dermatomes of the …