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The equilibration of labeled water (H215O) with the exchangeable water pool of brain was examined during a single capillary transit. The labeled water did not equilibrate freely when cerebral blood flow (CBF) exceeded 20 (ml/100 gm)/min in the rhesus monkey. At normal CBF .. 50 (ml/100 gm)/min only 90% of the injected bolus freely equilibrated with brain. This value progressively declined as CBF increased.
Raichle et al. (Mon,) studied this question.