Local left ventricular remodeling within infarcted myocardium was significantly greater than in non-infarcted myocardium (1.6% vs 0.3%, P=0.02) at one year following acute STEMI.
Cohort (n=46)
3D CMR co-registration demonstrates that local left ventricular remodeling is significantly greater in infarcted myocardium, particularly with >50% transmurality or microvascular obstruction.
Absolute Event Rate: 1.6% vs 0.3%
p-value: p=0.02
BACKGROUND: Progressive heart failure due to remodeling is a major cause of morbidity and mortality following myocardial infarction. Conventional clinical imaging measures global volume changes, and currently there is no means of assessing regional myocardial dilatation in relation to ischemic burden. Here we use 3D co-registration of Cardiovascular Magnetic Resonance (CMR) images to assess the long-term effects of ischemia-reperfusion injury on left ventricular structure after acute ST-elevation myocardial infarction (STEMI). METHODS: Forty six patients (age range 33-77 years) underwent CMR imaging within 7 days following primary percutaneous coronary intervention (PPCI) for acute STEMI with follow-up at one year. Functional cine imaging and Late Gadolinium Enhancement (LGE) were segmented and co-registered. Local left ventricular wall dilatation was assessed by using intensity-based similarities to track the structural changes in the heart between baseline and follow-up. Results are expressed as means, standard errors and 95% confidence interval (CI) of the difference. RESULTS: Local left ventricular remodeling within infarcted myocardium was greater than in non-infarcted myocardium (1.6%±1.0 vs 0.3%±0.9, 95% CI: -2.4% - -0.2%, P=0.02). One-way ANOVA revealed that transmural infarct thickness had a significant effect on the degree of local remodeling at one year (P20% (4.8%±1.4 vs -0.15%±1.2, 95% CI: -8.9% - -0.9%, P=0.017). CONCLUSIONS: The severity of ischemic injury has a significant effect on local ventricular wall remodeling with only modest dilatation observed within non-ischemic myocardium. Limitation of chronic remodeling may therefore depend on therapies directed at modulating ischemia-reperfusion injury. CMR co-registration has potential for assessing dynamic changes in ventricular structure in relation to therapeutic interventions.
O’Regan et al. (Sun,) conducted a cohort in Acute ST-elevation myocardial infarction (STEMI) (n=46). Infarcted myocardium vs. Non-infarcted myocardium was evaluated on Local left ventricular remodeling (95% CI -2.4% - -0.2%, p=0.02). Local left ventricular remodeling within infarcted myocardium was significantly greater than in non-infarcted myocardium (1.6% vs 0.3%, P=0.02) at one year following acute STEMI.
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