Chronic advanced aortic regurgitation in patients undergoing noncardiac surgery was associated with higher rates of in-hospital death (9% vs. 1.8%, P=0.008) and cardiopulmonary complications.
Cohort (n=334)
Does chronic advanced aortic regurgitation increase the risk of perioperative complications and mortality in patients undergoing noncardiac surgery?
Chronic advanced aortic regurgitation significantly increases the risk of cardiopulmonary complications and in-hospital mortality following noncardiac surgery.
Absolute Event Rate: 9% vs 1.8%
p-value: p=0.008
BACKGROUND: Whether and how chronic advanced aortic regurgitation (AR) impacts the perioperative outcome of noncardiac surgery remains unclear. METHODS: From November 1999 to December 2006, all patients undergoing noncardiac operations and ever examined by echocardiography within the last 6 months were screened. Those with chronic moderate-severe or severe AR were enrolled, provided they were not already trachea-intubated or aortic valve operated, and the surgery was not performed under local anesthesia. Case-matched subjects without significant AR served as controls. The perioperative outcomes of these patients were analyzed, and independent prognostic correlates were investigated by multivariate logistic regression analysis. RESULTS: A total of 167 patients (male 131, mean age of 75 years) complying with the enrollment criteria were studied. Compared with the other 167 case-matched control peers, patients with advanced AR risked potential hazards of serious hemodynamic instability (0.6%) and circulatory collapse (1.2%) during surgery despite the similar incidence of overall cardiac adverse events, and were further distressed with more cardiopulmonary complications (16.2% vs. 5.4%, P=0.003) and in-hospital deaths (9% vs. 1.8%, P=0.008) post-operatively. Multivariate regression analysis confirmed the correlation of advanced AR with perioperative mortality, and identified depressed left ventricular function, renal dysfunction, high surgical risk, and lack of cardiac medication as predictors of in-hospital death. CONCLUSION: Chronic advanced AR complicates the perioperative outcome of noncardiac surgery as reflected by frequent cardiopulmonary morbidities and in-hospital deaths, especially when coexisting with specified high-risk clinical and surgical characteristics.
Lai et al. (Mon,) conducted a cohort in Chronic advanced aortic regurgitation (n=334). Chronic advanced aortic regurgitation vs. No significant aortic regurgitation was evaluated on In-hospital deaths (p=0.008). Chronic advanced aortic regurgitation in patients undergoing noncardiac surgery was associated with higher rates of in-hospital death (9% vs. 1.8%, P=0.008) and cardiopulmonary complications.