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Clinical ApplicationsCoronary-Artery Disease Acute myocardial infarction. One of the striking developments in the past two years has been the ability to identify acutely infarcted myocardium with radiopharmaceuticals. Using 99mTc stannous pyrophosphate, Bonte, Parkey et al. have shown a high correlation between acute myocardial infarction confirmed by electrocardiography and enzyme studies and the appearance of a radioisotopic "hot spot" in the heart within five days after the acute event.20 , 21 Canine experiments involving coronary-artery ligation indicate that radiopharmaceuticals of this class accumulate in ischemic regions as well as infarcted areas after a threshold reduction in coronary blood flow is reached. . . .
Parisi et al. (Thu,) studied this question.