This research aims to investigate metabolic flexibility and its regulation in amino acid and polyamine pathways using heavy water labeling.
Utilized D₂O to track metabolic processes in mammalian cells.
Analyzed transport crosstalk between different metabolic pathways.
Assessed regulation across various cell types and tissues.
D₂O effectively measures metabolic flexibility in cells.
Significant differences in pathway regulation were observed across cell types and tissues.
Transport crosstalk was demonstrated, indicating interaction between different metabolic pathways.
Abstract
O and demonstrate that D₂O provides a sensitive readout of metabolic flexibility, transport crosstalk, and pathway regulation across cell types and tissues.
Demander à l'IA
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Gonzalez-Ibarra et al. (Fri,) studied this question.