What does this research mean for the field?

Ultrasound-stimulated barium titanate nanoparticles loaded with gentamicin (BTO-BSA-Gen) significantly reduce the incidence of implant-associated infections by inhibiting bacterial adhesion and potentiating aminoglycoside efficacy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim was to assess the potential of ultrasound-generated electricity from barium titanate to inhibit bacterial adhesion and enhance aminoglycoside efficacy in preventing implant-associated infections.

June 1, 2026Journal of Nanobiotechnology0 citationsOpen Access

Ultrasound-stimulated BTO-BSA-gen inhibits implant-associated infections by suppressing bacterial adhesion and potentiating aminoglycosides

JDJianing DingShanghai Jiao Tong University RHRenke HeShanghai Jiao Tong University STSiyue TaoShanghai Jiao Tong University

Key Points

The aim was to assess the potential of ultrasound-generated electricity from barium titanate to inhibit bacterial adhesion and enhance aminoglycoside efficacy in preventing implant-associated infections.
BTO nanoparticles generated ultrasound electricity to inhibit bacterial adhesion in biofilm formation.
Transcriptomics and metabolomics were employed to evaluate changes in S. aureus membrane molecules and toxin expression.
An ex vivo human skin model and animal studies were utilized to assess the efficacy of gentamicin-loaded BTO-BSA in reducing hematogenous implant-associated infections.
Mechanical stimulation reduced the frequency of hematogenous implant-associated infections from 83.7% to 25%.
BTO-BSA-Gen demonstrated significantly improved bactericidal effects against bacteria compared to controls.
Ultrasound delivery enhanced aminoglycoside effects, suggesting a novel 'bioelectric effect' mechanism.

Abstract

Biofilms render implant-associated infections (IAIs) particularly challenging to manage. Inhibiting bacterial adhesion, the initial stage of biofilm formation, holds great potential in alleviating IAIs. In this work, we proved that the ultrasound(US)-generated electricity provided by barium titanate nanoparticles (BTO) could inhibit bacterial adhesion. Transcriptomics and metabolomics results validated that the BTO under ultrasound reduces the amount of integral membrane molecules in S. aureus and suppresses the expression of toxin molecules. Moreover, ultrasound-generated electricity provided by BTO improved the effectiveness of aminoglycosides through "bioelectric effect". Based on these findings, we further synthesized gentamicin(gen) loaded BTO-BSA (BTO-BSA-Gen), which demonstrated promising bactericidal effects in an ex vivo human skin model. Animal studies show the engineered BTO-BSA-Gen could substantially safeguard implants against bacteremia, consequently diminishing the onset and severity of IAIs. The frequency of hematogenous IAIs decreased significantly from 83.7% to 25% in response to ultrasound following BTO-BSA-Gen administration. This research offers valuable insights for the development of noninvasive, wireless therapies for IAIs treatment.

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Cite This Study

Ding et al. (Fri,) studied this question.

synapsesocial.com/papers/6a1d21ba02fbce9130637a9f https://doi.org/https://doi.org/10.1186/s12951-026-04597-7

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