High serum triglycerides (≥150 mg/dL) were independently associated with increased arterial stiffness (OR 2.558) in subjects with LDL-C ≤79 mg/dL, but not in those with LDL-C ≥120 mg/dL.
Cross-Sectional (n=11,640)
No
Does high serum triglycerides increase arterial stiffness in a Japanese general population?
High serum triglycerides are independently associated with increased arterial stiffness in individuals with LDL-C ≤119 mg/dL, suggesting a residual cardiovascular risk that may warrant targeted therapy.
Effect estimate: OR 2.558 (95% CI 1.348-4.914)
Absolute Event Rate: 68.5% vs 37.6%
p-value: p=0.0040
BACKGROUND: The independent role of serum triglyceride (TG) levels as a cardiovascular risk factor is still not elucidated. We aimed to investigate if the effect of TG on arterial stiffness is influenced by the serum level of low-density lipoprotein cholesterol (LDL-C). METHODS AND RESULTS: We studied 11,640 subjects who underwent health checkups. They were stratified into 4 groups according to LDL-C level (≤79, 80-119, 120-159, and ≥160 mg/dL). Arterial stiffness was evaluated by brachial-ankle pulse wave velocity (baPWV). In each group, univariate and multivariete logistic regression analyses were performed to investigate the association between high TG (≥150 mg/dL) and high baPWV (>1,400 cm/s). In the univarite analysis, high TG was significantly associated with high baPWV in LDL-C <79 mg/dL (OR, 3.611, 95% CI, 2.475-5.337; P<0.0001) and 80-119 mg/dL (OR, 1.881; 95% CI, 1.602-2.210; P<0.0001), but not in LDL-C 120-159 mg/dL and ≥160 mg/dL. In the multivariate analysis, high TG was significantly associated with high baPWV in LDL-C ≤79 mg/dL (OR, 2.558; 95% CI, 1.348-4.914; P=0.0040) and LDL-C 80-119 mg/dL (OR, 1.677; 95% CI, 1.315-2.140; P<0.0001), but not in LDL-C 120-159 mg/dL and ≥160 mg/dL. CONCLUSIONS: High TG and increased arterial stiffness showed an independent relationship in a Japanese general population with LDL-C ≤119 mg/dL. TG-lowering therapy might be an additional therapeutic consideration in these subjects.
Kawasoe et al. (Wed,) conducted a cross-sectional in Arterial stiffness (n=11,640). High triglycerides (≥150 mg/dL) vs. Normal triglycerides (<150 mg/dL) was evaluated on High brachial-ankle pulse wave velocity (>1,400 cm/s) in subjects with LDL-C ≤79 mg/dL (OR 2.558, 95% CI 1.348-4.914, p=0.0040). High serum triglycerides (≥150 mg/dL) were independently associated with increased arterial stiffness (OR 2.558) in subjects with LDL-C ≤79 mg/dL, but not in those with LDL-C ≥120 mg/dL.
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