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The administration of 4-amino-PGA to dogs produced a sprue-like syndrome with diarrhea, peripheral leucopenia, depletion of bone marrow with increased numbers of hyper segmented polymorphonuclears and giant metamyelocytes, abnormal nuclear disintegration of normoblasts, change of nuclear pattern in erythroid elements and megalo-blasts. Doses given were lethal and animals succumbed with anorexia, weight loss, dehydration, and hemorrhagic diarrhea following severe ileitis and ulcerative colitis. It is suggested that the syndrome results from antagonism of folic acid.
Thiersch et al. (Fri,) studied this question.