What question did this study set out to answer?

This research aims to explore the link between serum PFAS mixtures and the risk of ovarian hyperstimulation syndrome (OHSS) in women undergoing assisted reproduction technology (ART).

June 3, 2026Open Access

Serum PFAS mixtures and risk of ovarian hyperstimulation syndrome in women undergoing assisted reproduction

Key Points

This research aims to explore the link between serum PFAS mixtures and the risk of ovarian hyperstimulation syndrome (OHSS) in women undergoing assisted reproduction technology (ART).
Identified associations between long-chain PFAS (PFNA, PFDA, and PFUdA) and heightened OHSS risk.
Utilized Bayesian kernel machine regression (BKMR) to analyze PFAS mixture effects.
Focused on younger women (<35 years) to assess susceptibility to PFAS exposure.
Long-chain PFAS were positively associated with increased risk of OHSS in ART.
BKMR analysis identified PFNA and OBS as key contributors to the risk of OHSS.
Younger women exhibited a greater susceptibility to the effects of PFAS exposure.

Abstract

• First study linking serum PFAS mixtures to OHSS risk in women undergoing ART. • Long-chain PFAS (PFNA, PFDA, and PFUdA) are positively associated with elevated OHSS risk. • BKMR identifies PFNA and OBS as dominant contributors to OHSS risk in mixture analyses. • Younger women (<35 years) show heightened susceptibility to PFAS exposure. • PFAS represent candidate environmental determinants of iatrogenic reproductive complications during ART.

Serum PFAS mixtures and risk of ovarian hyperstimulation syndrome in women undergoing assisted reproduction

Key Points

Abstract

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