Hypotension (aOR 4.01), severely reduced LVEF (aOR 3.68), severe renal dysfunction (aOR 3.29), and severe hyponatremia (aOR 4.14) were independently associated with in-hospital heart failure mortality.
Case-Control (n=313)
No
In a resource-limited setting in Cameroon, hypotension, severely reduced LVEF, severe renal dysfunction, and severe hyponatremia were identified as strong independent predictors of in-hospital mortality among heart failure patients.
Odds Ratio: 4.01 (95% CI 1.31–12.19)
p-value: p=0.015
Objective: Heart failure is a frequent and severe condition, associated with high in-hospital mortality and frequent readmissions. In resource-limited settings such as Cameroon, a better understanding of the factors associated with hospital mortality is crucial to optimize management and reduce lethality. To identify the factors associated with in-hospital mortality among patients hospitalized for heart failure at the Yaoundé University Teaching Hospital (CHU). Design and method: This was a retrospective study conducted in the internal medicine department of the Yaoundé University Teaching Hospital. The descriptive component aimed to determine the hospital prevalence of heart failure, while the analytical (case-control) component sought to identify factors independently associated with mortality. We included records of patients aged 18 years and above, hospitalized for confirmed heart failure. Results: Among the 1,918 hospitalization records reviewed during the study period, 313 patients were admitted for heart failure, corresponding to a hospital prevalence of 16.31% (95% CI: 14.61–17.99%). The delay between symptom onset and hospital admission was not independently associated with in-hospital mortality. However, several factors were significantly and independently associated with mortality: hypotension (aOR 4.01 1.31–12.19, p = 0.015), severely reduced left ventricular ejection fraction at admission (aOR 3.68 1.35–9.97, p = 0.010), severe renal dysfunction (aOR 3.29 1.16–9.36, p = 0.025), and severe hyponatremia (aOR 4.14 1.15–14.88, p = 0.029). Conclusions: This study highlights the severity of hospitalized heart failure decompensations, with several high-risk prognostic factors often present at admission. Early detection and targeted management of these factors could significantly reduce in-hospital mortality associated with heart failure in our context.
Ouankou et al. (Fri,) conducted a case-control in Heart failure (n=313). High-risk prognostic factors (e.g., hypotension) vs. Absence of these factors was evaluated on In-hospital mortality (aOR 4.01, 95% CI 1.31-12.19, p=0.015). Hypotension (aOR 4.01), severely reduced LVEF (aOR 3.68), severe renal dysfunction (aOR 3.29), and severe hyponatremia (aOR 4.14) were independently associated with in-hospital heart failure mortality.