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Forty years after the introduction of estrogens, the debate over the risks and benefits of estrogen replacement therapy in postmenopausal women is still not entirely settled.In contrast, the issues of testosterone replacement in older men are just beginning to be addressed.There is agreement that total, free, and bioavailable testosterone (ie, not bound by sex hormone-binding globulin) levels decline progressively with advancing age (Harman and Tsitouras,
Bhasin et al. (Mon,) studied this question.
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