A 6-month weight reduction program in obese volunteers significantly increased high molecular weight adiponectin from 0.37 to 0.40 μg/ml (P=0.042).
Observational (n=17)
Does a 6-month weight reduction program alter adiponectin oligomer composition in obese volunteers?
Moderate weight reduction in obese individuals leads to a relative increase in high and medium molecular weight adiponectin, which correlates with improvements in HDL cholesterol.
Absolute Event Rate: 0.4% vs 0.37%
p-value: p=0.042
Adiponectin affects lipid metabolism and insulin sensitivity. However, adiponectin circulates in three different oligomers that may also have distinct biological functions. We aimed to analyze the role of these oligomers in obesity and lipid metabolism after weight reduction. A total of 17 obese volunteers (15 women and 2 men) participated in a weight reduction program. Individuals were characterized before and after 6 months of a balanced diet. Adiponectin was determined by enzyme-linked immunosorbent assay, and oligomers were detected by nondenaturating Western blot. BMI decreased (35.1 +/- 1.2 to 32.8 +/- 1.1 kg/m(2), P < 0.001), which was associated with an improved metabolite profile. Total adiponectin increased from 5.3 +/- 0.5 to 6.1 +/- 0.6 microg/ml (P = 0.076). High (HMW) and medium molecular weight (MMW) adiponectin oligomers significantly increased during weight reduction (HMW: 0.37 +/- 0.07 to 0.4 +/- 0.08 microg/ml, P = 0.042; MMW: 2.3 +/- 0.2 to 2.9 +/- 0.3 microg/ml, P = 0.007), while low molecular weight (LMW) did not significantly change. Body weight inversely correlated with HMW (r = -0.695, P = 0.002) and positively with LMW (r = 0.579, P = 0.015). Interestingly, HDL cholesterol and HMW were strongly correlated (r = 0.665, P = 0.007). Indeed, HMW and free fatty acids before weight reduction predicted approximately 60% of HDL changes during intervention. In conclusion, weight reduction results in a relative increase of HMW/MMW adiponectin and a reduction of LMW adiponectin. Total adiponectin and especially HMW adiponectin are related to circulating HDL cholesterol.
Bobbert et al. (Thu,) conducted a observational in Obesity (n=17). Weight reduction program (balanced diet) vs. Baseline (before weight reduction) was evaluated on High molecular weight (HMW) adiponectin (μg/ml) (p=0.042). A 6-month weight reduction program in obese volunteers significantly increased high molecular weight adiponectin from 0.37 to 0.40 μg/ml (P=0.042).
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