Key points are not available for this paper at this time.
In this paper, we will demonstrate that both the content and the context of immunoglobulin genes change during the differentiation of lymphocytes. By content, we mean the genetic information used for coding immunoglobulin chains. By context, we mean the relative location of this information in DNA. The possibility of such changes has been the subject of much speculation in immunology, but only recently has it become possible to attack the problem directly. The principal technological advance which makes this possible has been the development of procedures for the purification of immunoglobulin mRNA from murine plasmacytomas (Tonegawa and Baldi 1973; Mach et al. 1973; Brownlee et al. 1973; Schechter 1973; Honjo et al. 1974; Stavnezer et al. 1974).
Tonegawa et al. (Sat,) studied this question.