Amyloid β-Protein and the Genetics of Alzheimer's Disease

The effort to decipher the mechanism of Alzheimer's disease (AD)1 has attracted the interest of investigators from diverse biological disciplines, including biochemistry, cell biology, molecular genetics, neuroscience, and structural biology. The eclectic nature of research approaches to AD and the intensity of scientific interest in the problem have made it increasingly likely that AD will become a premier example of the successful application of biological chemistry to the identification of rational therapeutic targets in a major human disease.