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INTRODUCTION IMGT/3Dstructure-DB is the three-dimensional (3D) structure database of IMGT, the international ImMunoGenetics information system that is acknowledged as the global reference in immunogenetics and immunoinformatics. IMGT/3Dstructure-DB contains 3D structures of (1) antigen receptors that comprise immunoglobulins (IG) or antibodies and T cell receptors (TR), (2) major histocompatibility (MH) proteins of class I (MH1) and class II (MH2), (3) peptide/MH (pMH) complexes (pMH1, pMH2), (4) antigen receptor/antigen complexes (IG/Ag, TR/pMH), and (5) related proteins of the immune system (RPI) belonging to the immunoglobulin and MH superfamilies (IgSF and MhSF, respectively) and found in complexes with IG, TR, or MH. IMGT/3Dstructure-DB data are annotated according to the IMGT criteria, using IMGT/DomainGapAlign, and based on the IMGT-ONTOLOGY axioms and concepts. The use of IMGT/3Dstructure-DB is described here. It provides IMGT gene and allele identification (CLASSIFICATION), region and domain delimitations (DESCRIPTION), and amino acid (AA) positions according to the IMGT unique numbering (NUMEROTATION). IMGT/3Dstructure-DB provides the closest genes and alleles that are expressed in the AA sequences of the 3D structures, by aligning these sequences with the IMGT domain reference directory.
Ehrenmann et al. (Wed,) studied this question.