In men, experiencing 3 to 6 childhood adversities was associated with a 1.44-fold increased risk of non-adherence to statin therapy compared to no adversities, while no association was seen in women.
Cohort (n=1,916)
Does exposure to childhood adversity predict non-adherence to statin therapy in adulthood?
Childhood adversity is a significant predictor of non-adherence to statin therapy in adult men, highlighting the potential impact of early psychosocial stress on cardiovascular prevention behaviors.
Relative Risk: 1.44 (95% CI 1.12–1.85)
p-value: p=0.013
PURPOSE: To investigate whether adverse experiences in childhood predict non-adherence to statin therapy in adulthood. METHODS: A cohort of 1378 women and 538 men who initiated statin therapy during 2008-2010 after responding to a survey on childhood adversities, was followed for non-adherence during the first treatment year. Log-binomial regression was used to estimate predictors of non-adherence, defined as the proportion of days covered by dispensed statin tablets <80%. In fully adjusted models including age, education, marital status, current smoking, heavy alcohol use, physical inactivity, obesity, presence of depression and cardiovascular comorbidity, the number of women ranged from 1172 to 1299 and that of men from 473 to 516, because of missing data on specific adversities and covariates. RESULTS: Two in three respondents reported at least one of the following six adversities in the family: divorce/separation of the parents, long-term financial difficulties, severe conflicts, frequent fear, severe illness, or alcohol problem of a family member. 51% of women and 44% of men were non-adherent. In men, the number of childhood adversities predicted an increased risk of non-adherence (risk ratio RR per adversity 1.11, 95% confidence interval CI 1.01-1.21], P for linear trend 0.013). Compared with those reporting no adversities, men reporting 3-6 adversities had a 1.44-fold risk of non-adherence (95% CI 1.12-1.85). Experiencing severe conflicts in the family (RR 1.27, 95% CI 1.03-1.57]) and frequent fear of a family member (RR 1.27, 95% CI 1.00-1.62]) in particular, predicted an increased risk of non-adherence. In women, neither the number of adversities nor any specific type of adversity predicted non-adherence. CONCLUSIONS: Exposure to childhood adversity may predict non-adherence to preventive cardiovascular medication in men. Usefulness of information on childhood adversities in identification of adults at high risk of non-adherence deserves further research.
Korhonen et al. (Tue,) conducted a cohort in Initiators of statin therapy (n=1,916). Childhood adversity vs. No childhood adversities was evaluated on Non-adherence to statin therapy (proportion of days covered <80%) (RR 1.44, 95% CI 1.12-1.85, p=0.013). In men, experiencing 3 to 6 childhood adversities was associated with a 1.44-fold increased risk of non-adherence to statin therapy compared to no adversities, while no association was seen in women.