IMMUNOHISTOLOGIC ANALYSIS OF INEFFECTIVE CD40-CD40 LIGAND INTERACTION IN LYMPHOID TISSUES FROM PATIENTS WITH X-LINKED IMMUNODEFICIENCY WITH HYPER-IgM

The functional development of B cell follicles and follicular dendritic cells require CD40-CD40 ligand interactions. Both of these abnormalities probably contribute to the immunodeficiency in HIGMX-1.