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The sites of deposition and the rates of clearance of a radiolabelled nasal spray solution have been monitored using gamma scintigraphy. In patients with nasal polyposis the rates of clearance were much slower than in normal subjects and in general were not improved following polypectomy. It may be inappropriate to administer systemically acting drugs by the intranasal route to patients with impaired nasal mucociliary function.
Lee et al. (Thu,) studied this question.