Pentacyclic triterpenoids from Ziziphus jujuba Lamk. fruits as dual inhibitors of PTP1B and α-glucosidase: in vitro and in silico evaluations

Key Points

• The study aims to evaluate the potential of pentacyclic triterpenoids from Ziziphus jujuba as dual inhibitors of PTP1B and alpha-glucosidase.
• Conducted in vitro evaluations of pentacyclic triterpenoids
• Performed in silico analyses to assess binding affinities
• Utilized standard biochemical assays for enzyme inhibition measurement.
• Pentacyclic triterpenoids showed significant inhibition of PTP1B with an IC50 value of X µM.
• Inhibition of alpha-glucosidase was observed with a Ki of Y µM.
• In silico results indicated favorable binding interactions with the active site of both enzymes.