Synthesis of Spirobenzo[ b thiophene-2(3 H ),1′-cyclopropan]-3-ones via Phosphine-Mediated 2 + 1 Cyclization and their Synthetic Transformations

Key Points

• The aim is to develop a method for synthesizing spiro[benzo[b]thiophene-2(3H),1′-cyclopropan]-3-ones and study their synthetic transformations.
• Phosphine-mediated [2 + 1] cyclization to form spiro compounds.
• Subsequent derivatizations to create fused dihydrofuran or furanone scaffolds.
• Conducted under mild conditions with a wide variety of substrates.
• Efficient synthesis of spiro[benzo[b]thiophene-2(3H),1′-cyclopropan]-3-ones achieved through phosphine mediation.
• Derivatization processes successfully yield valuable fused scaffolds.
• Broad substrate scope demonstrates the versatility of the synthetic method.