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We report a general and facile approach for the fabrication of a new class of monodispersed, single-component and thick-walled polymer nanocapsules via the single-step assembly of macromolecules in solid core/mesoporous shell (SC/MS) silica particle templates, followed by cross-linking of the macromolecules and removal of the SC/MS templates. The general applicability of this approach is demonstrated by the preparation of nanocapsules using various polymers, including synthetic polyelectrolytes, polypeptides, and polypeptide-drug conjugates. The potential of doxorubicin (Dox)-loaded poly(L-glutamic acid) nanocapsules in tumor therapy applications is demonstrated via in vitro degradation experiments, which show a near-linear release of the Dox in the presence of a lysosomal hydrolase, nanocapsule uptake by human colorectal tumor cells, and delivery of the anticancer drug into the tumor cells, leading to tumor cell death.
Wang et al. (Tue,) studied this question.