Heart failure with preserved ejection fraction (≥50%) was associated with significantly lower inhospital mortality, cardiac arrest, and shock compared to reduced ejection fraction (<50%).
Cohort (n=2,212)
Does heart failure with preserved ejection fraction (LVEF ≥50%) have different clinical presentations and inhospital outcomes compared to heart failure with reduced ejection fraction (LVEF <50%)?
Patients with HFPEF have lower inhospital mortality, cardiac arrest, and shock compared to those with reduced LVEF, a difference partially predicted by the use of evidence-based medications on admission.
We analyzed the clinical presentation and outcomes (from 2003 to 2013) of heart failure (HF) with apparently normal systolic function (HFPEF). Based on the echocardiographic left ventricular ejection fraction (LVEF), patients were divided into 2 groups, group 1 (<50%) and group 2 (≥50%). Of 2212 patients with HF, 20% were in group 2. Patients in group 2 were more likely to be older, females, Arabs, hypertensive, and obese (P = .001). Patients in group 1 were mostly Asians and had more troponin-T positivity (P = .001). Inhospital cardiac arrest, shock, and deaths were significantly greater in group 1. On multivariate analysis, age, ST-segment elevation myocardial infarction, lack of on-admission β-blockers, and angiotensin-converting enzyme inhibitors use were independent predictors of mortality. HFPEF is associated with less mortality compared to those who presented with reduced LVEF. On admission, use of evidence-based medications could in part predict this difference in the hospital outcome.
El‐Menyar et al. (Mon,) conducted a cohort in Heart failure (n=2,212). Preserved left ventricular ejection fraction (≥50%) vs. Reduced left ventricular ejection fraction (<50%) was evaluated on Inhospital cardiac arrest, shock, and deaths. Heart failure with preserved ejection fraction (≥50%) was associated with significantly lower inhospital mortality, cardiac arrest, and shock compared to reduced ejection fraction (<50%).