This review summarizes current knowledge on the acute regulation of ClC-1 channels in active skeletal muscles and its importance for muscle excitability, function, and fatigue.
This review highlights the critical role of ClC-1 chloride channels in maintaining skeletal muscle excitability and their implications for muscle fatigue.
Initiation and propagation of action potentials in muscle fibers is a key element in the transmission of activating motor input from the central nervous system to their contractile apparatus, and maintenance of excitability is therefore paramount for their endurance during work. Here, we review current knowledge about the acute regulation of ClC-1 channels in active muscles and its importance for muscle excitability, function, and fatigue.
Nielsen et al. (Thu,) conducted a review in Muscle fatigue. Acute regulation of ClC-1 channels was evaluated. This review summarizes current knowledge on the acute regulation of ClC-1 channels in active skeletal muscles and its importance for muscle excitability, function, and fatigue.