A 10-week physical-conditioning program increased the increment in fibrinolysis produced by venous occlusion from 21.7 to 33.8 units (P=0.0037).
Does a 10-week physical-conditioning program improve fibrinolytic activity at rest and after stimulation by venous occlusion in healthy adults?
A 10-week physical conditioning program enhances the fibrinolytic response to venous occlusion in healthy adults, suggesting a potential mechanism for the cardiovascular benefits of exercise.
Absolute Event Rate: 33.8% vs 21.7%
p-value: p=0.0037
The effects of a 10-week physical-conditioning program on fibrinolytic activity at rest and after stimulation by venous occlusion were studied in 69 healthy adults 25 to 69 years old. Physical conditioning was documented by treadmill performance, and fibrinolysis was measured with a newly developed radioenzymatic assay. Whereas fibrinolysis declined at rest from 16.2 +/- 1.3 to 11.4 +/- 0.8 units (mean +/- S.E.M.) (P = 0.0017), the increment in fibrinolysis produced by venous occlusion was increased from 21.7 +/- 2.9 to 33.8 +/- 4.7 units (P = 0.0037). This augmentation was most marked in women, persons with low initial levels of stimulated fibrinolysis, and persons with low initial physical fitness. We conclude that physical conditioning can enhance the augmentation of fibrinolytic activity that occurs in response to venous occlusion. Enhanced fibrinolysis in response to thrombotic stimuli could be an important mechanism in the beneficial effect of habitual physical activity on the risk of cardiovascular disease.
Williams et al. (Thu,) conducted a other in Healthy adults (n=69). Physical-conditioning program vs. Baseline (pre-conditioning) was evaluated on Increment in fibrinolysis produced by venous occlusion (p=0.0037). A 10-week physical-conditioning program increased the increment in fibrinolysis produced by venous occlusion from 21.7 to 33.8 units (P=0.0037).