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Mild cognitive impairment (MCI) is an early stage of Alzheimer's disease-related neurodegeneration and may occur in midlife. The objective of the study was to assess associations between plasma p-tau217, p-tau181, cognition, and multimorbidity. We studied 236 MCI patients and 210 controls. Cognition was assessed using the Mini-Mental State Examination and Montreal Cognitive Assessment. Multimorbidity was defined as ≥2 chronic conditions, and comorbidity as coexisting diseases. MCI was associated with lower cognition, higher p-tau levels, and greater multimorbidity. Plasma p-tau217 correlated inversely with cognition. Plasma p-tau reflects early neurodegeneration, with multimorbidity contributing to cognitive decline.
Bożek et al. (Thu,) studied this question.