Empirical mode decomposition features from ECG RR intervals significantly differentiated between T2DM patients with no CAN and established CAN, with specific features changing as CAN progressed.
Observational (n=60)
Do empirical mode decomposition (EMD)-based features from ECG RR interval signals differentiate between levels of cardiovascular autonomic neuropathy in patients with type 2 diabetes?
Empirical mode decomposition of heart rate variability signals can help characterize the progression of cardiovascular autonomic neuropathy in patients with type 2 diabetes.
In this study, we investigated the use of empirical mode decomposition (EMD)-based features extracted from electrocardiogram (ECG) RR interval signals to differentiate between different levels of cardiovascular autonomic neuropathy (CAN) in patients with type 2 diabetes mellitus (T2DM). This study involved 60 participants divided into three groups: no CAN, subclinical CAN, and established CAN. Six EMD features (area of analytic signal representation—ASRarea; area of the ellipse evaluated from the second-order difference plot—SODParea; central tendency measure of SODP—SODPCTM; power spectral density (PSD) peak amplitude—PSDpkamp; PSD band power—PSDbpow; and PSD mean frequency—PSDmfreq) were extracted from the RR interval signals and compared between groups. The results revealed significant differences between the noCAN and estCAN individuals for all EMD features and their components, except for the PSDmfreq. However, only some EMD components of each feature showed significant differences between individuals with noCAN or estCAN and those with subCAN. This study found a pattern of decreasing ASRarea and SODParea values, an increasing SODPCTM value, and a reduction in PSDbpow and PSDpkamp values as the CAN progressed. These findings suggest that the EMD outcome measures could contribute to characterizing changes associated with CAN manifestation in individuals with T2DM.
Cossul et al. (Mon,) conducted a observational in Type 2 diabetes mellitus (n=60). Empirical mode decomposition (EMD)-based features from ECG RR intervals vs. Between-group comparison (no CAN, subclinical CAN, established CAN) was evaluated on Differentiation between levels of cardiovascular autonomic neuropathy (CAN). Empirical mode decomposition features from ECG RR intervals significantly differentiated between T2DM patients with no CAN and established CAN, with specific features changing as CAN progressed.