Calcium and Hypertension: The Emerging Connection

Editorials1 December 1985Calcium and Hypertension: The Emerging ConnectionLAWRENCE M. RESNICK, M. D. LAWRENCE M. RESNICK, M. D. Author, Article, and Disclosure Informationhttps: //doi. org/10. 7326/0003-4819-103-6-944 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSince ringer first showed the importance of calcium in cardiac muscle contraction, a role for calcium has been increasingly recognized in mediating various cellular responses to external stimuli involved in neuromuscular function, stimulus-secretion coupling, and humoral target-organ effects. The use of calcium channel-blocking agents in the treatment of hypertension shows the critical importance of calcium in the biochemical control of vascular smooth muscle tone, and thus of blood pressure homeostasis. Despite these advances, the relation of clinical aspects of calcium metabolism such as dietary calcium intake, renal disposition of calcium, and circulating levels of calcium-regulating hormones, as well as of. . . References1. MCCARRONMORRIS DC. Blood pressure response to oral calcium in persons with mild to moderate hypertension: a randomized, double-blind, placebo-controlled, crossover trial. Ann Intern Med. 1985;103: 825-31. LinkGoogle Scholar2. JOHNSONSMITHFREUDENHEIM NEJ. Effects on blood pressure of calcium supplementation of women. Am J Clin Nutr. 1985;42: 12-7. CrossrefMedlineGoogle Scholar3. RESNICKSEALEYLARAGH LJJ. Short- and long-term oral calcium alters blood pressure (BP) in essential hypertension Abstract. Fed Proc. 1983;42: 300. Google Scholar4. KESTELOOTGEBOERS HJ. Calcium and blood pressure. Lancet. 1982;1: 813-5. CrossrefMedlineGoogle Scholar5. ERNEBOLLIBÜRGISSEBÜHLER PPEF. Correlation of platelet calcium with blood pressure: effect of antihypertensive therapy. 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Author, Article, and Disclosure InformationAffiliations: The New York Hospital-Cornell University Medical Center New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byOral Calcium Supplementation Reduces Intraplatelet Free Calcium Concentration and Insulin Resistance in Essential Hypertensive PatientsDietary calcium and blood pressure in experimental models of hypertension. A review. Effect of skim milk supplementation on blood cholesterol concentration, blood pressure, and triglycerides in a free-living human population. 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Calcium and Alcohol-Associated HypertensionSERGIO DE MARCHI, EMANUELA CECCHIN, RENZO CELLA, RENATO NARDINI 1 December 1985Volume 103, Issue 6Part₁Page: 944-946KeywordsBlood pressureCalciumCardiac musclesHormonesHypertensionSmooth muscles Issue Published: 1 December 1985 Copyright & Permissions©1985 American College of PhysiciansPDF downloadLoading. . .